Amino-PEG6-Alcohol With Cas.39160-70-8 Is For Chemical Modifications

Amino-PEG6-Alcohol With Cas.39160-70-8​ Is For Chemical Modifications

Synonyms:

H2N - PEG6 - OH ; 1 - AMinohexaethylene Glycol ; 17 - AMino - 3 , 6 , 9 , 12 , 15 -pentaoxaheptadecanol ; H₂N - PEG₆ - OH ; Amino - PEG6 - alcohol.

Introduction

The Amino-PEG6-Alcohol With Cas.39160-70-8 is used for modifying proteins or surfaces such as beads, nanoparticles and self-assembled monolayers. Modification of proteins adds polyethylene glycol (PEG)_n spacers, which impart increased water solubility, reduced immunogenicity of the labeled molecule and enhanced in vivo stability in solution. Functionalization of solid surfaces, such as quantum dots, self-assembled monolayers and nanoparticles, with polyethylene glycol spacers significantly reduces nonspecific protein binding. (PEG)n amine reagents used with (PEG)n amine reagents in surface modification can form a hydrophilic “lawn” of methyl ether-terminated PEGs with periodic exposed carboxy-terminated PEGs. The exposed carboxy groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

Typical PEGylation reagents contain heterogeneous mixtures of different PEG chain lengths; however, our PEGylation reagents are homogenous compounds of defined molecular weight and spacer length, providing precision in optimizing modification applications.