Provide Nanoparticle Reagents and Conjugation Technology 

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
Home ProductsAmino PEG

Amino-PEG2-Azide PEG Linker Contaning an Free Amine Group and a Azido Group

I'm Online Chat Now
Certification
China Wuhan Borenpharm Co., Ltd. certification
China Wuhan Borenpharm Co., Ltd. certification
We tested the 2,4,5-trimethyl-2,5-dihydro-1,3-thiazole in our assay and the results look good. It produced the expected stress response in our mice.

—— Kevin

Amino-PEG2-Azide PEG Linker Contaning an Free Amine Group and a Azido Group

Amino-PEG2-Azide PEG Linker Contaning an Free Amine Group and a Azido Group
Amino-PEG2-Azide PEG Linker Contaning an Free Amine Group and a Azido Group

Large Image :  Amino-PEG2-Azide PEG Linker Contaning an Free Amine Group and a Azido Group Get Best Price

Product Details:

Place of Origin: China
Brand Name: Borenpharm
Certification: www.borenpharm.com
Model Number: BK02158

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Price: negotiable
Packaging Details: 1g 5g 10g 25g
Delivery Time: Within 24 hours
Supply Ability: in stock
Detailed Product Description
CAS#: 166388-57-4 M.F.: C6H14N4O2
M.W.: 174.2 Appearance: Transparent And Oil Free Liquid
Purity: 95% Storage: -20℃ For Long Term
Item#: BK02158
High Light:

peg thiol

,

peg products

 

Amino-PEG2-Azide Is A Kind Of PEG Contaning An Amine Group

 

Item#:
BK02158
CAS#:
166388-57-4
M.F.:
C6H14N4O2
M.W.:
174.2
Appearance:
Transparent and oil free liquid
Purity:
95%
Storage:
-20℃ for Long Term

 

 

Introduction

The Amino-PEG2-Azide is used for modifying proteins or surfaces such as beads, nanoparticles and self-assembled monolayers. PEG Azides, a Polyethylene Glycol Building Blocks for PEGylation. It contaians a free amine group and an azido group, which The azide group enables Click Chemistry. Modification of proteins adds polyethylene glycol (PEG)n spacers, which impart increased water solubility, reduced immunogenicity of the labeled molecule and enhanced in vivo stability in solution. Functionalization of solid surfaces, such as quantum dots, self-assembled monolayers and nanoparticles, with polyethylene glycol spacers significantly reduces nonspecific protein binding. (PEG)n amine reagents used with (PEG)n amine reagents in surface modification can form a hydrophilic “lawn” of methyl ether-terminated PEGs with periodic exposed carboxy-terminated PEGs. The exposed carboxy groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

Typical PEGylation reagents contain heterogeneous mixtures of different PEG chain lengths; however, our PEGylation reagents are homogenous compounds of defined molecular weight and spacer length, providing precision in optimizing modification applications.

 

Amine-containing PEG linkers are widely used to modify water-soluble biopolymers (such as proteins) using water-soluble carbodiimides (such as EDC) to convert the carboxyl groups of the biopolymers into amide groups. Either NHS or NHSS may be used to improve the coupling efficiency of EDC-mediated protein– carboxylic acid conjugations. A large excess of the amine-PEG containing dyes is usually used for EDCmediated bioconjugations in concentrated protein solutions at low pH to reduce intra- and inter-protein coupling to lysine residues, a common side reaction. These dyes can also be used for modifications of carbohydrates, glycoproteins, and nucleic acids that are first periodate-oxidized to introduce aldehydes ketones into the biopolymers for subsequent reductive amination. The combination of periodate oxidation with reductive amination provides an effective way for site-selective modifications of biopolymers. For example, periodate oxidation of the 3’-terminal ribose is reported to be one of the few methods of selectively modifying RNA. Periodate-oxidized ribonucleotides are converted to fluorescent nucleotide probes by reaction with fluorescent-PEG hydrazines and amines.

Important Product Information

• The Amino-PEG2-Azide is low-melting solids that are difficult to weigh and dispense. To facilitate handling, make a stock solution by dissolving the reagent with dimethylsulfoxide (DMSO) or dimethylformamide (DMF).

• Use the (PEG)n amine reagents in combination with (PEG)n amine reagents to modify surfaces and minimize nonspecific binding.

• Use non-amine-containing buffers at pH 7-9 such as PBS (20mM sodium phosphate, 150mM NaCl; pH 7.4); 20mM HEPES; 100mM carbonate/biocarbonate; or 50mM borate. Do not use buffers that contain primary amines, such as Tris or glycine, which compete with acylation.

Contact Details
Wuhan Borenpharm Co., Ltd.

Contact Person: cathy

Send your inquiry directly to us